The influence of the physical environment of Class III inpatient rooms on patient satisfaction at Tgk Abdullah Syafi'i Beureunuen Hospital
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Abstract
Omega-3 fatty acids have garnered attention for their potential benefits in cardiovascular health and reproductive wellness. This study aimed to investigate the effects of omega-3 supplementation on blood cholesterol levels and ovulation events in trained individuals. A randomized controlled trial was conducted, involving physically active individuals aged 18-45 years engaged in regular exercise training. Participants were randomly assigned to receive either omega-3 supplementation or placebo for a specified duration. Blood lipid profiles, including total cholesterol, LDL-C, HDL-C, and triglyceride levels, were assessed using standardized laboratory assays. Ovulation events and menstrual cycle characteristics were monitored through hormonal assays, ultrasonographic imaging, and menstrual cycle tracking. Analysis of the findings revealed significant reductions in triglyceride levels following omega-3 supplementation, accompanied by trends towards improved LDL-C/HDL-C ratio. Moreover, enhancements in ovulatory function and menstrual cycle regularity were observed in physically active women receiving omega-3 supplementation. These findings underscore the potential benefits of omega-3 supplementation for optimizing cardiovascular and reproductive health outcomes in trained individuals. Future research endeavors should focus on elucidating the underlying mechanisms and conducting longitudinal studies to assess the sustained impact of omega-3 supplementation on health and performance in physically active populations.
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Bays, H. E., Tighe, A. P., Sadovsky, R., & Davidson, M. H. (2008). Prescription omega-3 fatty acids and their lipid effects: physiologic mechanisms of action and clinical implications. Expert Review of Cardiovascular Therapy, 6(3), 391–409.
Bianconi, S., Santillán, M. E., del Rosario Solís, M., Martini, A. C., Ponzio, M. F., Vincenti, L. M., Schiöth, H. B., Carlini, V. P., & Stutz, G. (2018). Effects of dietary omega-3 PUFAs on growth and development: Somatic, neurobiological and reproductive functions in a murine model. The Journal of Nutritional Biochemistry, 61, 82–90.
Calder, P. C. (2014). Very long chain omega‐3 (n‐3) fatty acids and human health. European Journal of Lipid Science and Technology, 116(10), 1280–1300.
Corral-Jara, K. F., Cantini, L., Poupin, N., Ye, T., Rigaudière, J. P., Vincent, S. D. Saint, Pinel, A., Morio, B., & Capel, F. (2020). An integrated analysis of mirna and gene expression changes in response to an obesogenic diet to explore the impact of transgenerational supplementation with omega 3 fatty acids. Nutrients, 12(12), 3864.
Denis, I., Potier, B., Vancassel, S., Heberden, C., & Lavialle, M. (2013). Omega-3 fatty acids and brain resistance to ageing and stress: body of evidence and possible mechanisms. Ageing Research Reviews, 12(2), 579–594.
Ferin, M., Jewelewicz, R., & Warren, M. P. (1993). The menstrual cycle: physiology, reproductive disorders, and infertility. Oxford University Press, USA.
Gerling, C. (2013). The Effects of Omega-3 Supplementation on Human Skeletal Muscle Sarcolemmal and Mitochondrial Membrane Fatty Acid Composition and Whole Body Substrate Oxidation. University of Guelph.
Howe, P., & Buckley, J. (2014). Metabolic health benefits of long-chain omega-3 polyunsaturated fatty acids. Military Medicine, 179(suppl_11), 138–143.
Hu, J., Zhang, Z., Shen, W.-J., & Azhar, S. (2010). Cellular cholesterol delivery, intracellular processing and utilization for biosynthesis of steroid hormones. Nutrition & Metabolism, 7, 1–25.
Jacobs, R. D. (2015). Dietary supplementation of omega-3 fatty acids influences the equine maternal uterine environment and embryonic development. Virginia Polytechnic Institute and State University.
Kazemi, M., McBreairty, L. E., Chizen, D. R., Pierson, R. A., Chilibeck, P. D., & Zello, G. A. (2018). A comparison of a pulse-based diet and the therapeutic lifestyle changes diet in combination with exercise and health counselling on the cardio-metabolic risk profile in women with polycystic ovary syndrome: a randomized controlled trial. Nutrients, 10(10), 1387.
Kotwal, S., Jun, M., Sullivan, D., Perkovic, V., & Neal, B. (2012). Omega 3 fatty acids and cardiovascular outcomes: systematic review and meta-analysis. Circulation: Cardiovascular Quality and Outcomes, 5(6), 808–818.
Leslie, M. A., Cohen, D. J. A., Liddle, D. M., Robinson, L. E., & Ma, D. W. L. (2015). A review of the effect of omega-3 polyunsaturated fatty acids on blood triacylglycerol levels in normolipidemic and borderline hyperlipidemic individuals. Lipids in Health and Disease, 14, 1–18.
Lesser, W. P. (2014). Physician decision criteria regarding omega-3 dietary supplements. Walden University.
Mason, R. P., Libby, P., & Bhatt, D. L. (2020). Emerging mechanisms of cardiovascular protection for the omega-3 fatty acid eicosapentaenoic acid. Arteriosclerosis, Thrombosis, and Vascular Biology, 40(5), 1135–1147.
McKinley-Barnard, S. K., Andre, T. L., Gann, J. J., Hwang, P. S., & Willoughby, D. S. (2018). Effectiveness of fish oil supplementation in attenuating exercise-induced muscle damage in women during midfollicular and midluteal menstrual phases. The Journal of Strength & Conditioning Research, 32(6), 1601–1612.
Mickleborough, T. D. (2013). Omega-3 polyunsaturated fatty acids in physical performance optimization. International Journal of Sport Nutrition and Exercise Metabolism, 23(1), 83–96.
Otto, J. R., Freeman, M. J., Malau-Aduli, B. S., Nichols, P. D., Lane, P. A., & Malau-Aduli, A. E. O. (2014). Reproduction and fertility parameters of dairy cows supplemented with omega-3 fatty acid-rich canola oil. Annual Research & Review in Biology, 4, 1611–1636.
Phelan, N., O’Connor, A., Tun, T. K., Correia, N., Boran, G., Roche, H. M., & Gibney, J. (2011). Hormonal and metabolic effects of polyunsaturated fatty acids in young women with polycystic ovary syndrome: results from a cross-sectional analysis and a randomized, placebo-controlled, crossover trial. The American Journal of Clinical Nutrition, 93(3), 652–662.
Prior, J. C. (2019). The menstrual cycle: its biology in the context of silent ovulatory disturbances. In Routledge international handbook of Women’s sexual and reproductive health (pp. 39–54). Routledge.
Sahebkar, A., Simental-Mendía, L. E., Mikhailidis, D. P., Pirro, M., Banach, M., Sirtori, C. R., & Reiner, Ž. (2018). Effect of omega-3 supplements on plasma apolipoprotein C-III concentrations: a systematic review and meta-analysis of randomized controlled trials. Annals of Medicine, 50(7), 565–575.
Saldeen, P., & Saldeen, T. (2004). Women and omega-3 Fatty acids. Obstetrical & Gynecological Survey, 59(10), 722–730.
Simopoulos, A. P., & Cleland, L. G. (2003). Omega-6/omega-3 essential fatty acid ratio: the scientific evidence (Vol. 92). Karger Medical and Scientific Publishers.
Zhao, J., Chen, J., Li, M., Chen, M., & Sun, C. (2020). Multifaceted functions of CH25H and 25HC to modulate the lipid metabolism, immune responses, and broadly antiviral activities. Viruses, 12(7), 727.
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